Hydrochloric Acid → HCID 13559602, compound

Participants

Reaction Steps

2.9 Grams of methyl 2-(4-chlorobenzoylamino)-3-(3-methyloxindol-3-yl)propionate prepared in Example 48 was added to 10 ml of 10%-hydrochloric acid and the mixture was refluxed for 3 hours. After cooling, the reaction mixture was extracted with chloroform, the extract was washed with water and dried with anhydrous magnesium sulfate. The solvent was removed by evaporation, the residue was dissolved in a saturated sodium bicarbonate aqueous solution, then the resulting solution was filtered with Celite (trademark for diatomaceous earth product manufactured by Johns-Manville Products Corp.) as a filter aid. The filtrate was acidified with 10%-hydrochloric acid, the crystals formed were collected by filtration to obtain 230 mg of 2-(4-chlorobenzoylamino)-3-(3-methyloxindol-3-yl)propionic acid in the form of white powdery substance.

Provenance & Evidence