Benzyl 2-aminoacetate hydrochloride → 4-(2,3,4,6-Tetra-O-acetyl-beta-D-glucopyranosyloxy)-3-[2-(4-(2-[1-carboxy-1-(methyl)ethylcarbamoyl]ethyl)phenyl)ethyl]-benzofuran

Participants

Role	Name	HCID	Charge
Reactant	Benzyl 2-aminoacetate hydrochloride	HCID 11701227	—
Reactant	Benzyl 2-amino-2-methylpropanoate hydrochloride	HCID 21415531	—
Reactant	4-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyloxy)-3-{2-[4-(2-carboxyethyl)phenyl]ethyl}benzofuran	HCID 67136080	—
Product	4-(2,3,4,6-Tetra-O-acetyl-beta-D-glucopyranosyloxy)-3-[2-(4-(2-[1-carboxy-1-(methyl)ethylcarbamoyl]ethyl)phenyl)ethyl]-benzofuran	HCID 67135820	—

Reaction Steps

The title compound was prepared in a similar manner to that described in Example 84 using 4-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxy)-3-{2-[4-(2-carboxyethyl)phenyl]ethyl}benzofuran and benzyl 2-amino-2-methylpropionate hydrochloride instead of 4-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxy)-3-[2-(4-carboxyphenyl)ethyl]benzofuran and benzyl 2-aminoacetate hydrochloride, respectively.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07566699B2
Source dataset	uspto-grants-2009_07
ORD ID	ord-927103ee21e943099b81ccaf457821df
Source note	uspto-grants-2009_07