Ethanolamine → 2-Pentyl-2-oxazoline

HRID 2309309Notes

Reaction equation

HRID 2309309 reaction equation
[CH2:1]([CH2:3][NH2:4])[OH:2].[C:5](#N)[CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]>[O-2].[Cd+2].C(O)(=O)C>[CH2:6]([C:5]1[O:2][CH2:1][CH2:3][N:4]=1)[CH2:7][CH2:8][CH2:9][CH3:10]

Participants

5

Reactant 2

HCID 700EthanolamineHCID 12352Hexanenitrile

Product 1

HCID 146517902-Pentyl-2-oxazoline

Reagents, catalysts & solvents 2

HCID 10197697Cadmium OxideCatalystHCID 176Acetic AcidSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of about 3.24 grams cadmium oxide, about 3.00 grams acetic acid, about 64.8 grams ethanolamine, and about 98.2 grams hexanenitrile is heated and stirred under nitrogen at about 120 degrees C. to 125 degrees C. for about two days. The liquid is decanted from the catalyst and distilled under vacuum. The fraction boiling at about 86 degrees C. to about 93 degrees C. at about 28 mmHg to about 30 mm Hg is collected.

Workup

  1. temperatureis heated
  2. customto 125 degrees C
  3. customThe liquid is decanted from the catalyst
  4. distillationdistilled under vacuum
  5. customto about 93 degrees C
  6. customat about 28 mmHg to about 30 mm Hg is collected

Sources & evidence

ORD record
ord-78d9ab365af94d6a8efb1647285bb012
Source dataset
uspto-grants-1987_09
Patent number
US04695295

Reaction notes

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