Ethanolamine → 2-Phenyl-2-oxazoline

HRID 2309312Notes

Reaction equation

HRID 2309312 reaction equation
[C:1](#[N:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:9]([CH2:11]N)[OH:10]>O.O.C([O-])(=O)C.[Cd+2].C([O-])(=O)C>[C:2]1([C:1]2[O:10][CH2:9][CH2:11][N:8]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 700EthanolamineHCID 7505Benzonitrile

Product 1

HCID 2440302-Phenyl-2-oxazoline

Reagents, catalysts & solvents 1

HCID 6537495Cadmium acetate, dihydrateCatalyst

Conditions

Temperature
125 °C

Procedure

A mixture of about 104.1 grams (1.0 mole) benzonitrile, about 63.1 grams (1.03 mole) ethanolamine, and about 6.2 grams (0.025 mole) cadmium acetate dihydrate is heated and stirred at about 125 degrees C. to about 130 degrees C. under nitrogen for about two days. The product is distilled under vacuum and the fraction boiling at about 120 degrees C. to about 121 degrees C. at 16 mmHg is collected.

Workup

  1. temperatureis heated
  2. customto about 130 degrees C
  3. distillationThe product is distilled under vacuum
  4. customto about 121 degrees C
  5. customat 16 mmHg is collected

Sources & evidence

ORD record
ord-72932923184a4d938189aca8428cc071
Source dataset
uspto-grants-1987_09
Patent number
US04695295

Reaction notes

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