2,2-Dimethyl-2,3-dihydro-1-benzofuran-7-sulfonyl isocyanate → N-[(4-Cyclopropyl-6-methylpyrimidin-2-yl)amino-carbonyl]-2,3-dihydro-2,2-dimethyl-7-benzofuransulfonamide

Participants

Reaction Steps

To a suspension of 0.47 g of 2-amino-4-cyclopropyl-6-methylpyrimidine in 15 ml of methylene chloride is added one g of the sulfonyl isocyanate prepared in Example 4. After stirring at room temperature overnight, the suspension is concentrated in vacuo, and the residue is triturated with 1-chlorobutane and filtered to give the subject compound.

Provenance & Evidence