Triethylamine → HCID 178469348, compound

Participants

Reaction Steps

5.0 g. (18.5 mmol) 3-methyl-3-ethoxycarbonyl-6-aminoindolin-2-one hydrochloride are suspended in 60 ml. methylene chloride and mixed with 12.5 ml. (90.4 mmol) triethylamine. 6.4 g. (45.2 mmol) pyrazine-2-carboxylic acid chloride are then added portionwise, while cooling with ice, and the reaction mixture is further stirred for 3 hours. The reaction mixture is evaporated, worked up with water, filtered off with suction and purified by column chromatography elution agent: methylene chloride/methanol 99:1 v/v). There are obtained 4.0 g. (65% of theory) of the title compound; m.p.

Provenance & Evidence