HCID 14479916, compound → HCID 178469348, compound

HRID 2309372Notes

Reaction equation

[CH3:1][C:2]1([C:24]([O:26][CH2:27][CH3:28])=[O:25])[C:10]2[C:5](=[CH:6][C:7]([NH:14][C:15]([C:17]3[CH:22]=[N:21][CH:20]=[CH:19][N:18]=3)=O)=[C:8]([N+:11]([O-])=O)[CH:9]=2)[NH:4][C:3]1=[O:23]>[Pd].C(O)C>[CH3:1][C:2]1([C:24]([O:26][CH2:27][CH3:28])=[O:25])[C:10]2[C:5](=[CH:6][C:7]3[NH:14][C:15]([C:17]4[CH:22]=[N:21][CH:20]=[CH:19][N:18]=4)=[N:11][C:8]=3[CH:9]=2)[NH:4][C:3]1=[O:23]

Participants

Conditions

Temperature: 60 °C

Procedure

3.2 g. (8.3 mmol) 3-methyl-3-ethoxycarbonyl-5-nitro-6-(2-pyrazinoylamino)-indolin-2-one in 100 ml. ethanol are hydrogenated in 100 ml. ethanol in the presence of 0.5 g. 10% palladium on charcoal. After completion of the take up of hydrogen, the solution is filtered off from the catalyst, the ethanol is evaporated off and the residue is stirred for 1 hour in glacial acetic acid at 60° C.

Workup

filtrationAfter completion of the take up of hydrogen, the solution is filtered off from the catalyst
customthe ethanol is evaporated off

Sources & evidence

ORD record: ord-f7db87b5e6424637847c79674aea29c4
Source dataset: uspto-grants-1987_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04695567

Reaction notes

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