Pipecolic acid, (-)- → Pipecolic Acid

HRID 2309376Notes

Reaction equation

HRID 2309376 reaction equation
[CH2:1]1[CH2:6][C@@H:5]([C:7]([OH:9])=[O:8])[NH:4][CH2:3][CH2:2]1>O>[NH:4]1[CH2:3][CH2:2][CH2:1][CH2:6][CH:5]1[C:7]([OH:9])=[O:8]

Participants

3

Reactant 1

HCID 439227Pipecolic acid, (-)-

Product 1

HCID 849Pipecolic Acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The filtrate is evaporated and dissolved in 5% acetic acid. Finally the solution is treated with Amberlite IR 45* in an ion exchanger. The eluate thus obtained is evaporated and the resulting crystalline residue is dried with potassium hydroxide in vacuo. The product obtained consists of L-pipecolic acid [α]24D -26.2°(C=5**, H2O).

Workup

  1. customThe filtrate is evaporated
  2. dissolutiondissolved in 5% acetic acid
  3. additionFinally the solution is treated with Amberlite IR 45* in an ion exchanger
  4. customThe eluate thus obtained
  5. customis evaporated
  6. dry with materialthe resulting crystalline residue is dried with potassium hydroxide in vacuo
  7. customThe product obtained

Sources & evidence

ORD record
ord-9084e86048ed490f8685a6aaecd86184
Source dataset
uspto-grants-1987_09
Patent number
US04695576

Reaction notes

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