4-Hydroxybenzaldehyde → Benzaldehyde, 4-(phenylmethoxy)-

Participants

Reaction Steps

A solution of p-hydroxybenzaldehyde (3.66 g, 30 mmole) in dry DMF (20 ml) was stirred with anhydrous potassium carbonate (12.5 g, 90 mmole) and benzylbromide (6.16 g, 36 mmole) was added. After 18 hours, the mixture was diluted with brine (75 ml) and extracted three times with ether. The extracts were combined, washed with dilute brine, dried over anhydrous magnesium sulfate and evaporated in vacuo to afford a solid. Crystallization from ethyl ether in hexane gave 5 g of title E compound as light yellow flakes, with consistent spectral data.

Provenance & Evidence