N-carbobenzyloxyalanine → HCID 178445951, compound

Participants

Reaction Steps

From 0.63 g (1.01 mM) of carbobenzoxy-glycyl-phenylalanyl-leucyl-arginine and 0.38 g (1.11 mM) of p-nitrophenyl ester of carbobenzoxy-alanine, in a manner similar to that described hereinbefore, 0.56 g (79%) of carbobenzoxy-alanyl-glycyl-phenylalanyl-leucyl-arginine with m.p. of 147°-149° C. is obtained. [α]D25 =-4.0 (c 0.5, dimethylformamide). Rf1 =0.33 (C), Rf2 =0.35 (D), Rf3 =0.67 (chloroform:methanol: 32% acetic acid 60:45:20) (E).

Provenance & Evidence