Benzaldehyde → HCID 54351713, compound

Participants

Reaction Steps

11 g of methyl 5-propanoyl-2-hydroxy-benzeneacetic acid, 10,6 g of benzaldehyde, 150 ml of ethanol and 50 ml of ether saturated with hydrogen chloride are refluxed for 5 days. The solution is poured on to water and extracted with ethyl acetate. The ethyl acetate is evaporated and the residue is hydrolyzed in sodium hydroxide solution. The pH is adjusted to 7 and the solution is washed with ethyl acetate. The aqueous phase is acidified with hydrochloric acid and extracted with ethyl acetate. The ethyl acetate is evaporated, the residue is leached with dichloroethane and recrystallized from 2-butanone/1,2-dichloroethane. NMR spectrum and elemental analysis data are consistent with the structure of the title compound. Melting point 192° C.

Provenance & Evidence