HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2309678Generated: November 3, 2026
Ethyl 3-amino-3-methylbutanoate → Ethyl 3-[(4-bromobutyl)aminocarbonylamino]-3-methylbutanoate
https://huagongshe.com/reaction/2309678
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl 3-amino-3-methylbutanoate | HCID 11480520 | — |
| Reactant | 1-Bromo-4-isocyanatobutane | HCID 14971584 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 3-[(4-bromobutyl)aminocarbonylamino]-3-methylbutanoate | HCID 20184474 | 95% |
Reaction Steps
A solution of 4-bromobutylisocyanate (15.1 g) in methylene chloride (50 ml) is added to a stirred solution of ethyl 3-amino-3-methylbutanoate (12.3 g), dissolved in methylene chloride (50 ml) at -20° C. The mixture is stirred for 30 minutes at -20° C. and then for an additional 2 hours at room temperature. Evaporation of the solvent yields a residue of ethyl 3-[(4-bromobutyl)aminocarbonylamino]-3-methylbutanoate (26 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04696927 |
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| Source dataset | uspto-grants-1987_09 |
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| ORD ID | ord-d021e12515424ff3a33414c07576d365 |
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| Source note | uspto-grants-1987_09 |
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