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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2309682Generated: October 30, 2026

Hydrochloric Acid → Pyridine, 3-(3-chloropropyl)-, hydrochloride

https://huagongshe.com/reaction/2309682

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant3-PyridinepropanolHCID 17861—
ReactantPhosphorus oxychlorideHCID 24813—
SolventEthyl AcetateHCID 8857—
SolventSodium HydroxideHCID 14798—
ProductPyridine, 3-(3-chloropropyl)-, hydrochlorideHCID 205439—

Reaction Steps

3-(3-Pyridyl)propyl chloride hydrochloride was prepared in quantitative yield by reacting 3-(3-pyridyl)propanol with phosphorus oxychloride in ethyl acetate at reflux temperature. The free base was generated by dissolving the hydrochloride in a 10% sodium hydroxide solution and extracting with an organic solvent (toluene or ether).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04696920
Source datasetuspto-grants-1987_09
ORD IDord-65cf91a57628444487d9d93d49435361
Source noteuspto-grants-1987_09