HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → HCID 8688636, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | 1-Phenylpiperazine | HCID 7096 | — |
| Reactant | 4-(Bromomethyl)benzonitrile | HCID 86996 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 8688636 | HCID 8688636 | 79.3% |
Reaction Steps
4-phenylpiperazine (41.4 g, 0.26 mol) was added to a solution of 4-(bromomethyl)benzonitrile (25 g, 0.13 mol) in 60 ml ethanol and the mixture was refluxed for one hour. After filtration of the precipitated N-phenylpiperazinium bromide, the filtrate was evaporated and the residue was recrystallized in a chloroform: acetone mixture to afford 28.6 g (79% yield) of 4-(4-phenylpiperazinylmethyl)benzonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04696920 |
| Source dataset | uspto-grants-1987_09 |
| ORD ID | ord-06b683f5898a44bd8292d67b7bed1b0f |
| Source note | uspto-grants-1987_09 |