Diltiazem → 1,2-Benzothiazepine

HRID 2309685Notes

Reaction equation

HRID 2309685 reaction equation
CC(O[C@H:5]1[C:15](=O)[N:14](CCN(C)C)C2C=CC=CC=2S[C@H:6]1[C:22]1[CH:23]=[CH:24][C:25](OC)=[CH:26][CH:27]=1)=O.CCOP(OCC)(CC1C=CC(C2[S:50]C3C=CC=CC=3N=2)=CC=1)=O>>[S:50]1[C:27]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[CH:6]=[CH:5][CH:15]=[N:14]1

Participants

3

Reactant 2

HCID 39186DiltiazemHCID 53421Fostedil

Product 1

HCID 179290841,2-Benzothiazepine

Procedure

Diltiazem, KB-944 (Fostedil)

Sources & evidence

ORD record
ord-47732346c24e41d7be3da264ab4b56c5
Source dataset
uspto-grants-1987_09
Patent number
US04696920

Reaction notes

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