1-Benzylpiperazine → HCID 135838364, compound

Participants

Reaction Steps

8-Chloro-1,2-dihydro-4-phenylimidazo[1,2-a]pyrido[3,2-e]pyrazine 5-oxide (3 g, 0.01 mol) and benzylpiperazine (3.6 g, 0.02 mol) were heated at 80° C., in isopropanol (100 ml) under an atmosphere of nitrogen for 16 hrs. As the reaction mixture cooled to room temperature, a yellow solid precipitated. The yellow solid was collected by filtration, washed with cold isopropanol and recrystallized from isopropanol to yield 1,2-dihydro-4-phenyl-8-(4-phenylmethylpiperazinyl)imidazo [1,2-a]pyrido[3,2-e]pyrazine 5-oxide (3.7 g), as orange needles, m.p. 184°-187° C. (Found: C,71.03; H,6.02; N,19.30%; C26H24N6O.O.1H2O requires C,70.92; H,6.00; N,19.09%), represented by the structural formula: ##STR30##

Provenance & Evidence