Pyridine → HCID 20137146, compound

Participants

Reaction Steps

A mixture of 2-(4-cyanobutyl)-4-aminopyrimidine (1.0 g.), n-propylisothiocyanate (0.57 g.) and pyridine (25 ml.) was heated under reflux for 3 hours. The solvent was removed by evaporation in vacuo and the residue was purified by medium pressure chromatography on silica gel using CHCl3 /MeOH 9.75:0.25 v/v as eluant. The purified product (0.85 g.) in EtOH (10 ml.) was added to EtOH saturated with ammonia (30 ml.) and mercuric oxide (0.6 g.). After 15 minutes the reaction mixture was filtered through diatomaceous earth and the filtrate was evaporated to give 5-(4-[2-propylguanidino]pyrimid-2-yl)valeronitrile (0.85 g.) which was used without further purification.

Provenance & Evidence