Ethyl isothiocyanate → HCID 54522826, compound

HRID 2309714Notes

Reaction equation

HRID 2309714 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([S:8][CH2:9][CH2:10][CH2:11][C:12]([NH2:14])=[O:13])[N:3]=1.[CH2:15]([N:17]=[C:18]=[S:19])[CH3:16]>C(#N)C>[CH2:15]([NH:17][C:18](=[S:19])[NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([S:8][CH2:9][CH2:10][CH2:11][C:12]([NH2:14])=[O:13])[N:3]=1)[CH3:16]

Participants

4

Reactant 2

HCID 10966Ethyl isothiocyanateHCID 20184634HCID 20184634, compound

Product 1

HCID 54522826HCID 54522826, compoundYield 70.8%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 4-(2-aminopyrid-6-ylthio)butyramide (0.25 g.), ethylisothiocyanate (0.2 g.) and acetonitrile (5 ml.) was heated under reflux for 18 hours and then cooled, and the solid which crystallised was collected to give 4-[2-(3-ethylthioureido)pyrid-6-ylthio]butyramide (0.25 g.) which was used without further purification.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 18 hours
  3. temperaturecooled
  4. customthe solid which crystallised
  5. customwas collected

Sources & evidence

ORD record
ord-79a685f3153a46e4b849d123fb19ac6c
Source dataset
uspto-grants-1987_09
Patent number
US04696933

Reaction notes

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