Ammonia → HCID 54054840, compound

HRID 2309717Notes

Reaction equation

HRID 2309717 reaction equation
[CH2:1]([NH:4][C:5](=S)[NH:6][C:7]1[CH:11]=[CH:10][N:9]([CH2:12][CH2:13][CH2:14][CH2:15][C:16]#[N:17])[N:8]=1)[CH2:2][CH3:3].[NH3:19]>>[CH2:1]([N:4]=[C:5]([NH2:19])[NH:6][C:7]1[CH:11]=[CH:10][N:9]([CH2:12][CH2:13][CH2:14][CH2:15][C:16]#[N:17])[N:8]=1)[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 53930108HCID 53930108, compound

Product 1

HCID 54054840HCID 54054840, compound

Procedure

A solution of 5-(3-[3-propylthioureido]pyrazol-1-yl)valeronitrile (1.01 g.) in saturated methanolic ammonia (30 ml.) was treated with orange mercuric oxide (0.82 g.) and the suspension stirred at room temperature for 18 hours. The black suspension was filtered through diatomaceous earth and the filtrate evaporated to give 5-(3-[2-propylguanidino]pyrazol-1-yl)valeronitrile as a brown oil which was used without further purification.

Workup

  1. filtrationThe black suspension was filtered through diatomaceous earth
  2. customthe filtrate evaporated

Sources & evidence

ORD record
ord-8867f46ddb65467c98e43709ec350ac3
Source dataset
uspto-grants-1987_09
Patent number
US04696933

Reaction notes

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