HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2309724Generated: October 27, 2026
Triethylamine → ethyl (S)-4-[[1-(aminocarbonyl)propyl]amino]butyrate
https://huagongshe.com/reaction/2309724
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl 4-bromobutyrate | HCID 76300 | — |
| Reactant | (2S)-2-Aminobutanamide hydrochloride | HCID 11961924 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | ethyl (S)-4-[[1-(aminocarbonyl)propyl]amino]butyrate | HCID 29938336 | — |
Reaction Steps
143.6 ml (1.035 mole) of triethylamine are added to a suspension of 47.75 g (0.345 mole) of (S)-2-amino-butanamide hydrochloride ([alpha]D25 : +26.1°; c=1, methanol) in 400 ml of toluene. The mixture is heated to 80° C. and 67.2 g (0.345 mole) of ethyl 4-bromobutyrate are introduced dropwise.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04696943 |
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| Source dataset | uspto-grants-1987_09 |
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| ORD ID | ord-79b3e9246e9248dfb84d77acd5058582 |
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| Source note | uspto-grants-1987_09 |
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