反应详情

4.2 g of 6-(2-chlorophenyl)-2-methylpyridine was dissolved in 100 ml dioxane, 1.8 g of selenium dioxide (Aldrich, Gold Label) was added and the mixture was refluxed for 16 hours. The solution was decanted, fresh selenium dioxide (1.8 g) was added and refluxing was continued for a further 4 days. The solids were filtered and 250 ml ether was added. The organic solution was washed five times with 50 ml H2O, dried over magnesium sulfate. Evaporation afforded an oil which was filtered through silica gel eluting with 30% ether-hexane to afford 3.2 g of 6-(2-chlorophenyl)-2-pyridinecarboxaldehyde as a pale yellow solid.

1. temperaturethe mixture was refluxed for 16 hours
2. customThe solution was decanted
3. additionfresh selenium dioxide (1.8 g) was added
4. temperaturerefluxing
5. filtrationThe solids were filtered
6. addition250 ml ether was added
7. washThe organic solution was washed five times with 50 ml H2O
8. dry with materialdried over magnesium sulfate
9. customEvaporation
10. customafforded an oil which
11. filtrationwas filtered through silica gel eluting with 30% ether-hexane