反应详情

6-(2-bromophenyl)-2-methylpyridine (3.5 g) was dissolved in 150 ml 1,4-dioxane. Selenium dioxide (Aldrich, Gold Label, 2.0 g) was added and the mixture was refluxed for a total of 50 hours. The solids were removed by filtration and the mixture was diluted with ether. The solution was washed several times with water, dried over magnesium sulfate, filtered and evaporated to afford 2.0 g of crude 6-(2-bromophenyl)-2-pyridinecarboxaldehyde as a yellow semi-solid.

1. temperaturethe mixture was refluxed for a total of 50 hours
2. customThe solids were removed by filtration
3. additionthe mixture was diluted with ether
4. washThe solution was washed several times with water
5. dry with materialdried over magnesium sulfate
6. filtrationfiltered
7. customevaporated