HuagongsheHuagongshe Chemistry Print Report · For research reference only
Selenium Dioxide → 6-(2-Fluorophenyl)pyridine-2-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Selenium Dioxide | HCID 24007 | — |
| Reactant | 2-(2-Fluorophenyl)-6-methylpyridine | HCID 21275758 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6-(2-Fluorophenyl)pyridine-2-carbaldehyde | HCID 20184683 | — |
Reaction Steps
2.0 g of 6-(2-fluorophenyl)-2-methylpyridine was dissolved in 250 ml of 1,4-dioxane. Selenium dioxide (2.67 g, Aldrich Gold Label) was added and the mixture was reluxed for 6 days. The solids were removed by filtration and the dioxane was evaporated. The crude 6-(2-fluorophenyl)-2-pyridinecarboxaldehyde was purified by chromatography on silica gel to afford pure 6-(2-fluorophenyl)-2-pyridinecarboxaldehyde.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04696938 |
| Source dataset | uspto-grants-1987_09 |
| ORD ID | ord-475e5e75db414212a90837a0e5d814a5 |
| Source note | uspto-grants-1987_09 |