Pyridine → 10-Propionyl dithranol

Participants

Reaction Conditions

Reaction Steps

To a suspension of 56.6 g (0.25 mol) of purified anthralin in 1750 m3 of anhydrous toluene at room temperature, 27.3 cm3 (0.34 mol) of anhydrous pyridine was added first and then 26.2 cm3 (0.3 mol) of propionyl chloride was added dropwise in around 20 minutes. The mixture was then heated to around 85° C. for 1 hour. The mixture was recooled to room temperature, 27.3 cm3 of pyridine and 26.2 cm3 of propionyl chloride were again added and the mixture was heated for 1 hour to a temperature of around 85° C.

Provenance & Evidence