HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2309752Generated: October 30, 2026
Diethyl Ether → N-Benzyl-N-methoxy-1-phenylmethanamine
https://huagongshe.com/reaction/2309752
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | O-Methylhydroxylamine hydrochloride | HCID 521874 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-Benzyl-N-methoxy-1-phenylmethanamine | HCID 17883627 | — |
Reaction Steps
A mixture of 5.11 g of methoxylaminehydrochloride, 20.87 g of benzylbromide and 25.8 g of sodium carbonate in 50 ml of dimethylformamide is heated at 85° C. for 4 hrs. The reaction mixture is treated with ether and water. The organic phase is separated and washed with water, dried (MgSO4) and evaporated under reduced pressure. Flash column chromatography of the residue affords the title compound as a clear colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04696964 |
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| Source dataset | uspto-grants-1987_09 |
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| ORD ID | ord-1131ffbe0dcd48968f451b016116a15c |
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| Source note | uspto-grants-1987_09 |
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