HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2309757Generated: November 2, 2026
2-Phenylacetophenone → HCID 13298045, compound
https://huagongshe.com/reaction/2309757
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Phenylacetophenone | HCID 9948 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Tetrahydropyranyl ether | HCID 263182 | — |
| Catalyst | Benzyl triethylammonium chloride | HCID 66133 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 13298045 | HCID 13298045 | — |
Reaction Steps
A mixture containing 19.6 g of desoxybenzoin, 20.9 g of tetrahydropyran-2-yl ether-protected bromoethanol, 1.0 g of TEBAC and 50 ml of 48% sodium hydroxide solution is stirred for 2 h at 75° C. Water is added and the product extracted in toluene. The toluene solution is washed with water and dried over sodium sulfate. Finally the solvent is evaporated. The yield is quantitative, but the oily product contains about 20% O-alkylation product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04696949 |
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| Source dataset | uspto-grants-1987_09 |
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| ORD ID | ord-d0a99e28b727424c92e5d48d644b0f63 |
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| Source note | uspto-grants-1987_09 |
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