4-Methoxy cinnamic acid → 4-Methoxycinnamic acid chloride

Participants

Reaction Steps

p-Methoxycinnamic acid (52.7 g=0.45 mole) was slurried under N2 in 500 mL of sieve-dried dichloroethane. Oxalyl chloride (146.0 gm=1.15 moles) was added in one portion followed by three drops of DMF. Complete solution was achieved in 30 minutes. The solution was stirred an additional 2 hours, and then the dichloroethane containing excess oxalyl chloride was removed on a 50° C. rotary evaporator. Fresh dichloroethane was twice added to the residue and removed on the rotary evaporator. The amber oil was used without purification. Yield 90.4 gm.

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