HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2309820Generated: November 2, 2026
Water → 2-(3,4-Dimethoxyphenyl)-2-(propan-2-yl)pentanedinitrile
https://huagongshe.com/reaction/2309820
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Propanenitrile, 3-methoxy- | HCID 61032 | — |
| Reactant | 2-(3,4-Dimethoxyphenyl)-3-methylbutanenitrile | HCID 89396 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(3,4-Dimethoxyphenyl)-2-(propan-2-yl)pentanedinitrile | HCID 13628268 | — |
Reaction Steps
438.4 g (2 mol) of α-isopropyl-veratryl cyanide and 204.2 g (2.4 mol) of 3-methoxypropionitrile are dissolved in 400 ml of dimethylformamide, 36 ml of a 5.5 molar solution of sodium methylate are added, and the mixture is heated to 85° C. for 1/2 hour. After cooling, water is added to the reaction mixture and the reaction product separates by crystallisation. Recrystallised from methanol/water, the product melts at 97° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04697035 |
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| Source dataset | uspto-grants-1987_09 |
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| ORD ID | ord-19da2e56868341a7839664ea9f1d4fe6 |
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| Source note | uspto-grants-1987_09 |
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