4,5-Diaminopyrimidine → 2-(2'-Methoxy-4'-chlorosulfonyl-phenyl)-purine hydrochloride

HRID 2309861Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2309861
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([S:12]([Cl:15])(=[O:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5](O)=O.[NH2:16][C:17]1[C:22]([NH2:23])=[CH:21][N:20]=[CH:19][N:18]=1>>[ClH:15].[CH3:1][O:2][C:3]1[CH:11]=[C:10]([S:12]([Cl:15])(=[O:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5]1[N:16]=[C:17]2[C:22]([NH:23][CH:19]=[N:18]2)=[CH:21][N:20]=1

Komponenten

3

Edukt 2

HCID 837034,5-DiaminopyrimidineHCID 201845804-(Chlorosulfonyl)-2-methoxybenzoic acid

Produkt 1

HCID 201845292-(2'-Methoxy-4'-chlorosulfonyl-phenyl)-purine hydrochloride

Versuchsvorschrift

Prepared analogously to Example C from 2.5 gm of 2-methoxy-4-chlorosulfonyl benzoic acid and 2.4 gm of 4,5-diamino-pyrimidine (crystalline product obtained from dihydrochloride and 1 mol of common salt) by refluxing for eight hours. The solid crude product was processed further without any purification.

Aufarbeitung

  1. temperatureby refluxing for eight hours
  2. customThe solid crude product was processed further without any purification

Quellen und Nachweise

ORD-Eintrag
ord-960828db7cb74670a598895fc7b94ba4
Quelldatensatz
uspto-grants-1987_09
Patentnummer
US04696931

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