1,4-Dioxane → 4-[6-(2-Chloro-4-fluoro-benzoylamino)-pyridin-2-yloxy]-2-methyl-piperidine-1-carboxylic acid tert-butyl ester

HRID 2309946Notes

Reaction equation

HRID 2309946 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([CH3:22])[CH2:10][CH:11]([O:14][c:15]2[n:16][c:17]([NH2:21])[cH:18][cH:19][cH:20]2)[CH2:12][CH2:13]1.[CH2:34]1[O:35][CH2:36][CH2:37][O:38][CH2:39]1.[Cl:23][c:24]1[c:25]([C:26](=[O:27])[Cl:28])[cH:29][cH:30][c:31]([F:33])[cH:32]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([CH3:22])[CH2:10][CH:11]([O:14][c:15]2[n:16][c:17]([NH:21][C:26]([c:25]3[c:24]([Cl:23])[cH:32][c:31]([F:33])[cH:30][cH:29]3)=[O:27])[cH:18][cH:19][cH:20]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 312751,4-DioxaneHCID 27365462-Chloro-4-fluorobenzoyl chlorideHCID 690712164-(6-Amino-pyridin-2-yloxy)-2-methyl-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 690663474-[6-(2-Chloro-4-fluoro-benzoylamino)-pyridin-2-yloxy]-2-methyl-piperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-3bf2d2cb107649e1b81332ee180cdc4f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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