2-(1-Benzofuran-2-yl)acetic acid → N-[(benzofuran-2-yl)acetyl]alanine Iso-butyl Ester

HRID 23100Notes

Reaction equation

HRID 23100 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[CH2:10][C:11]([OH:13])=O.[CH2:14]([O:18][C:19](=[O:23])[C@H:20]([CH3:22])[NH2:21])[CH:15]([CH3:17])[CH3:16]>>[CH2:14]([O:18][C:19](=[O:23])[C@H:20]([CH3:22])[NH:21][C:11](=[O:13])[CH2:10][C:2]1[O:1][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=1)[CH:15]([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 111058882-(1-Benzofuran-2-yl)acetic acidHCID 137435562-methylpropyl (2S)-2-aminopropanoate

Product 1

HCID 15481779N-[(benzofuran-2-yl)acetyl]alanine Iso-butyl Ester

Procedure

Following General Procedure BI above, and using benzofuran-2-ylacetic acid (Maybridge) and alanine iso-butyl ester (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-ab471bac6d094e2a9c0501687a753f5b
Source dataset
uspto-grants-2005_02
Patent number
US06849650B2

Reaction notes

Loading…