4-Hydroxybenzoic Acid → 4-{[(Benzyloxy)carbonyl]oxy}benzoic acid

Participants

Reaction Steps

To an aqueous solution of 55 m moles(7.6 g) of 4-hydroxybenzoic acid and 65 m moles(2.6 g) of sodium hydroxide in 200 ml of water, 65 m moles(10.6 g) of carbobenzoxychloride was added dropwise at 0° C. After 24 hours, the precipitate was washed with water, filtered, and dried, then purified by column chromatography to obtain 15.0 g of 4-carbobenzoxyoxybenzoic acid [m.p. 181.9°-183.1° C⟧ (yield: 99%)

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