HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 231031Generated: November 1, 2026
Formaldehyde → Indole-2,3-dione, 1-(hydroxymethyl)-
https://huagongshe.com/reaction/231031
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Isatin | HCID 7054 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Solvent | Water | HCID 962 | — |
| Product | Indole-2,3-dione, 1-(hydroxymethyl)- | HCID 39834 | 93% |
Reaction Steps
Isatin (25 g, 0.17 mol) and 30% formalin (30 ml, 0.3 mol) were added to a mixture of dioxane (10 ml) and water (20 ml) and the mixture was heated at 100° C. for 5 hours. The reaction mixture was cooled and crystals formed were filtered off. N-hydroxymethylisatin (28 g, yield 93%) was obtained. The melting point was 138° C. (decomposed).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04845020 |
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| Source dataset | uspto-grants-1989_07 |
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| ORD ID | ord-e300c7d5fad146689fff82c67bdf00df |
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| Source note | uspto-grants-1989_07 |
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