HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → N-Chloromethylisatin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Indole-2,3-dione, 1-(hydroxymethyl)- | HCID 39834 | — |
| Product | N-Chloromethylisatin | HCID 12207287 | — |
Reaction Steps
N-Hydroxymethylisatin (10 g, 0.056 mol) was added to thionyl chloride (100 ml) and the mixture was heated under reflux for 2 hours. N-Chloromethylisatin (about 11 g) was obtained by distilling the remaining thionyl chloride under reduced pressure. The melting point was 121° to 123° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04845020 |
| Source dataset | uspto-grants-1989_07 |
| ORD ID | ord-5334c4e95c64423ba49a5bf357cb5e8e |
| Source note | uspto-grants-1989_07 |