2-Fluoro-5-(trifluoromethyl)phenyl isocyanate → 1-(2-Fluoro-5-(trifluoromethyl)phenyl)-3-(4-(3-methyl-2-oxo-1,2-dihydropyrido[2,3-b]pyrazin-8-yloxy)naphthalen-1-yl)urea

HRID 2310452Notes

Reaction equation

HRID 2310452 reaction equation
[F:25][c:26]1[c:27]([N:36]=[C:37]=[O:38])[cH:28][c:29]([C:32]([F:33])([F:34])[F:35])[cH:30][cH:31]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]([O:12][c:13]2[cH:14][cH:15][n:16][c:17]3[n:18][c:19]([CH3:24])[c:20](=[O:23])[nH:21][c:22]23)[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12>>[NH:1]([c:2]1[cH:3][cH:4][c:5]([O:12][c:13]2[cH:14][cH:15][n:16][c:17]3[n:18][c:19]([CH3:24])[c:20](=[O:23])[nH:21][c:22]23)[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12)[C:37]([NH:36][c:27]1[c:26]([F:25])[cH:31][cH:30][c:29]([C:32]([F:33])([F:34])[F:35])[cH:28]1)=[O:38]

Participants

3

Reactant 2

HCID 27333802-Fluoro-5-(trifluoromethyl)phenyl isocyanateHCID 469012518-(4-aminonaphthalen-1-yloxy)-3-methylpyrido[2,3-b]pyrazin-2(1H)-one

Product 1

HCID 441337271-(2-Fluoro-5-(trifluoromethyl)phenyl)-3-(4-(3-methyl-2-oxo-1,2-dihydropyrido[2,3-b]pyrazin-8-yloxy)naphthalen-1-yl)urea

Sources & evidence

ORD record
ord-745e786e9aa04e98a121786929e2d8e3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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