Diazomethane → HCID 13853699, compound

HRID 231081Notes

Reaction equation

HRID 231081 reaction equation
[C:1]([C:4]1[CH:23]=[CH:22][C:7]([O:8][CH2:9][CH2:10][CH2:11][S:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]([OH:21])=[O:20])=[CH:15][N:14]=2)=[C:6]([CH2:24][CH2:25][CH3:26])[C:5]=1[OH:27])(=[O:3])[CH3:2].[N+](=[CH2:30])=[N-]>CO.CCOCC>[C:1]([C:4]1[CH:23]=[CH:22][C:7]([O:8][CH2:9][CH2:10][CH2:11][S:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]([O:21][CH3:30])=[O:20])=[CH:15][N:14]=2)=[C:6]([CH2:24][CH2:25][CH3:26])[C:5]=1[OH:27])(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 9550DiazomethaneHCID 13853698HCID 13853698, compound

Product 1

HCID 13853699HCID 13853699, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Conditions

Temperature
0 °C

Procedure

The compound of Example 1 (500 mg, 1.284 mmoles) was dissolved in mixture of CH3OH (10 ml) and ether (10 ml) cooled to 0° C. Diazomethane was added until a slight yellow color persisted. The reaction mixture was concentrated to afford the title compound, m.p. 66°-68°.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-791f8cbf7a0c4753bc5d0132b7dbb3fc
Source dataset
uspto-grants-1989_07
Patent number
US04845108

Reaction notes

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