Water → HCID 13853701, compound

Participants

Reaction Steps

The compound of Example 3, (570 mg, 1.31 mmoles) was dissolved in THF (6 ml) to which was added 1N NaOH (3 ml) and H2O (3 ml). The reaction mixture was stirred at room temperature under N2 overnight. The THF was removed in vacuo. The aqueous phase was washed with CHCl3. Then the aqueous phase was acidified with concentrated HCl until slightly acid (pH about 5-6). The resulting beige solid was filtered, taken up in CHCl3 (about 500 ml), and the organic solvent was dried and concentrated. The residue was triturated with ether and filtered to afford the title compound, m.p. 177°-179°.

Provenance & Evidence