Aniline → HCID 13568664, compound

HRID 231103Notes

Reaction equation

HRID 231103 reaction equation
O1[CH2:6][CH2:5][N:4]([C:7]([C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[NH:15][C:14](=[O:19])[CH2:13][CH2:12]3)=[O:8])[CH2:3][CH2:2]1.[NH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[C:21]1([N:20]2[CH2:6][CH2:5][N:4]([C:7]([C:9]3[CH:10]=[C:11]4[C:16](=[CH:17][CH:18]=3)[NH:15][C:14](=[O:19])[CH2:13][CH2:12]4)=[O:8])[CH2:3][CH2:2]2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 6115AnilineHCID 131953376-(Morpholine-4-carbonyl)-3,4-dihydroquinolin-2(1H)-one

Product 1

HCID 13568664HCID 13568664, compound

Procedure

2.62 Grams of 6-morpholinocarbonyl-3,4-dihydrocarbostyril and 10 g of aniline were placed in a sealed tube and heated at 170°-200° C. for 5 hours. Excess aniline was removed by evaporation under reduced pressure, then the residue thus obtained was purified by means of silica gel column chromatography. Recrystallized from isopropanol to obtain 0.32 g of 6-(4-phenyl-1-piperazinylcarbonyl)-3,4-dihydrocarbostyril. Colorless needle-like crystals. Melting point: 200°-201° C.

Workup

  1. temperatureheated at 170°-200° C. for 5 hours
  2. customExcess aniline was removed by evaporation under reduced pressure
  3. customthe residue thus obtained
  4. customwas purified by means of silica gel column chromatography
  5. customRecrystallized from isopropanol

Sources & evidence

ORD record
ord-dc275cf8de2e483cba4ebe7baee714f0
Source dataset
uspto-grants-1989_07
Patent number
US04845100

Reaction notes

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