Ethylene Glycol → HCID 13883909, compound

Participants

Reaction Steps

10.0 g of 5-chloro-4-[2-(4-formylmethyl-2-methylphenoxy)ethylamino]-6-methylpyrimidine and 3.0 g of ethylene glycol were dissolved in 300 ml of toluene. A small amount of p-toluenesulfonic acid was added to the solution, and the reaction vessel was equipped with a device for quantitatively determining water. The mixture was then heated under reflux for 8 hours. At the end of this time, the reaction mixture was washed with water and dried over anhydrous sodium sulfate. Toluene was removed by distillation under reduced pressure and the oily product thus obtained was subjected to column chromatography (Wakogel C-200, eluted with a 2:1 by volume mixture of toluene and ethyl acetate) to isolate the product and give 7.9 g of the title compound as a colorless oily liquid, n23.4 =1.5730.

Provenance & Evidence