Hydrochloric Acid → HCID 19980527, compound

Participants

Reaction Conditions

Reaction Steps

A solution of ethyl 3-(2-phenyl-1-cyclopropyl)-2-(m-nitrophenylmethylen)-3-oxo-propanoate (5 g) and ethyl-3-aminocrotonate (1.6 g) in EtOH (50 ml) is heated to the reflux temperature for 4 hours, then it is cooled at 0° C., acidified with concentrated aqueous HCl (0.2 ml) and stirred at 0° C. for 30 minutes. After neutralization with a few drops of a saturated Na2HPO4 water solution, the mixture is evaporated and the residue is dissolved in AcOEt (60 ml), washed with water (3×10 ml), dried on Na2SO4 and purified on silica gel (200 g, eluent: diisopropylether/Et ether/Et2O 80/20) to give 4.0 g of 2-(2-phenyl-1-cyclopropyl)-3,5-dicarboethoxy-4-(m-nitrophenyl)-6-methyl-1,4-dihydropyridine amorphous solid.

Provenance & Evidence