Ethyl 5-chloro-beta-oxo-alpha,2-bis(phenylmethoxy)benzenepropanoate → 6-Chloro-3,4-dihydroxy-2H-1-benzopyran-2-one

Participants

Reaction Steps

Catalytic hydrogenation. A solution of ethyl 5-chloro-β-oxo-α,2-bis(phenylmethoxy)benzenepropanoate (0.88 g, 0.002 mol) in 20 ml of EtOAc was hydrogenated over 0.18 g of 10% Pd/C at room temperature and 35 psi for 2 h. After filtration, the solvent was removed under reduced pressure affording a light yellow oil. The oil was treated as previously described, affording 0.293 g (69%) of 6-chloro-3,4-dihydroxy-2H-1-benzopyran-2-one as white solid.

Provenance & Evidence