HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Acetamidothiazole → beta-oxo-2-[(1-oxo-2-butenyl)-amino]-N-(2-thiazolyl)-3-trifluoromethyl-benzene-proponamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Acetamidothiazole | HCID 17625 | — |
| Reactant | 2-Amino-3-(trifluoromethyl)benzoic acid | HCID 604569 | — |
| Reactant | trans-Crotonyl chloride | HCID 643131 | — |
| Reactant | 2-(1-propenyl)-8-trifluoromethyl-4H-3,1-benzoxazin-4-one | HCID 57218882 | — |
| Product | beta-oxo-2-[(1-oxo-2-butenyl)-amino]-N-(2-thiazolyl)-3-trifluoromethyl-benzene-proponamide | HCID 131715994 | 70.6% |
Reaction Steps
Using the procedure of Step A of Example 1, 19.44 g of 2-acetylamino thiazole and 17.3 g of 2-(1-propenyl)-8-trifluoromethyl-4H-3,1-benzoxazin-4-one [prepared by Step A of Example 12 of European Pat. No. 40,573 from crotonyl chloride and 2-amino-trifluoromethyl benzoic acid] were reacted to obtain 19.03 g of β-oxo-2-[(1-oxo-2-butenyl)-amino]-N-(2-thiazolyl)-3-trifluoromethyl-benzene-proponamide melting at 206°-208° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04845105 |
| Source dataset | uspto-grants-1989_07 |
| ORD ID | ord-49d68b511b0b4ce6be305d0ff9949c2c |
| Source note | uspto-grants-1989_07 |