HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopentylacetic acid → N-(cyclopentylacetyl)-L-alanine Iso-butyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopentylacetic acid | HCID 71606 | — |
| Reactant | 2-Methylpropyl (2S)-2-aminopropanoate hydrochloride | HCID 86584981 | — |
| Product | N-(cyclopentylacetyl)-L-alanine Iso-butyl Ester | HCID 54023872 | — |
Reaction Steps
Following General Procedure BB above, and using cyclopentylacetic acid (Aldrich) and L-alanine iso-butyl ester hydrochloride (from Example BB above), the title compound was prepared as a solid having a melting point of 62° C.-64° C. The reaction was monitored by tlc on silica gel (Rf=0.37 in 1:3 EtOAc:hexane) and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06849650B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-759f28cc195f45dcac582d3bf1a38aaf |
| Source note | uspto-grants-2005_02 |