2-(Chloromethyl)-4-methoxypyridine hydrochloride → 2-(4-Methoxy-2-picolylmercapto)-1H-thieno[3,4-d]imidazole dihydrochloride

HRID 231151Notes

Reaction equation

HRID 231151 reaction equation
[SH:1][C:2]1[NH:3][C:4]2[C:5](=[CH:7][S:8][CH:9]=2)[N:6]=1.[ClH:10].[CH3:11][O:12][C:13]1[CH:18]=[CH:17][N:16]=[C:15]([CH2:19][Cl:20])[CH:14]=1>C(O)C>[ClH:20].[ClH:10].[CH3:11][O:12][C:13]1[CH:18]=[CH:17][N:16]=[C:15]([CH2:19][S:1][C:2]2[NH:6][C:5]3=[CH:7][S:8][CH:9]=[C:4]3[N:3]=2)[CH:14]=1

Participants

4

Reactant 2

HCID 139233682-(Chloromethyl)-4-methoxypyridine hydrochlorideHCID 178527818HCID 178527818, compound

Product 1

HCID 139233702-(4-Methoxy-2-picolylmercapto)-1H-thieno[3,4-d]imidazole dihydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.6 g of 2-mercaptothieno[3,4-d]imidazole and 2 g of 4-methoxypicolyl chloride hydrochloride in 50 ml of ethanol were heated at 60° C. for about one hour and stirred at room temperature for a further 40 hours. After the crystalline substance had been filtered off, it was suspended in acetone, the mixture was stirred at room temperature for one hour, and the crystals were filtered off with suction and dried in air. Colorless crystals, melting point 330° C.

Workup

  1. filtrationAfter the crystalline substance had been filtered off
  2. stirringthe mixture was stirred at room temperature for one hour
  3. filtrationthe crystals were filtered off with suction
  4. customdried in air

Sources & evidence

ORD record
ord-bbda3d16c9cf44989d8ce969123fe544
Source dataset
uspto-grants-1989_07
Patent number
US04845118

Reaction notes

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