Ethyl 4-(bromomethyl)benzoate → ethyl 4-[(2'-oxo-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3'-indol]-1'(2'H)-yl)methyl]benzoate

HRID 2311964Notes

Reaction equation

HRID 2311964 reaction equation
[Br:44][CH2:45][c:46]1[cH:47][cH:48][c:49]([C:50](=[O:51])[O:52][CH2:53][CH3:54])[cH:55][cH:56]1.[CH2:57]([O:58][c:59]1[cH:60][cH:61][c:62]([CH2:63][Cl:64])[n:65][cH:66]1)[c:67]1[cH:68][cH:69][cH:70][cH:71][cH:72]1.[NH:1]1[C:2](=[O:22])[C:3]2([CH2:4][O:5][c:6]3[cH:7][c:8]4[c:9]([cH:14][c:15]32)[O:10][CH2:11][CH2:12][O:13]4)[c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]21.[NH:23]1[c:24]2[c:25]([cH:26][cH:27][cH:28][cH:29]2)[C:30]2([c:31]3[c:32]4[c:33]([cH:34][cH:35][c:36]3[O:37][CH2:38]2)[n:39][o:40][n:41]4)[C:42]1=[O:43]>>[N:1]1([CH2:45][c:46]2[cH:47][cH:48][c:49]([C:50](=[O:51])[O:52][CH2:53][CH3:54])[cH:55][cH:56]2)[C:2](=[O:22])[C:3]2([CH2:4][O:5][c:6]3[cH:7][c:8]4[c:9]([cH:14][c:15]32)[O:10][CH2:11][CH2:12][O:13]4)[c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]21

Participants

5

Reactant 4

HCID 954261Ethyl 4-(bromomethyl)benzoateHCID 178541585-(Benzyloxy)-2-(chloromethyl)pyridineHCID 58224164Spiro[furo[2,3-g]-1,4-benzodioxin-8(7H),3'-[3H]indol]-2'(1'H)-one, 2,3-dihydroHCID 593526377H-spiro[benzofuro[4,5-c][1,2,5]oxadiazole-8,3'-indolin]-2'-one

Product 1

HCID 59352738ethyl 4-[(2'-oxo-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3'-indol]-1'(2'H)-yl)methyl]benzoate

Sources & evidence

ORD record
ord-7b06a49957f04bf1874f6a02b2ce8f9e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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