Methanol → HCID 20034702, compound

HRID 231197Notes

Reaction equation

HRID 231197 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:13][C:14]2([CH2:20][C:21]3[CH:26]=[C:25]([O:27][CH3:28])[C:24]([O:29][CH3:30])=[C:23]([O:31][CH3:32])[CH:22]=3)SCCCS2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].IC.C[OH:36]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:13][C:14]([CH2:20][C:21]2[CH:26]=[C:25]([O:27][CH3:28])[C:24]([O:29][CH3:30])=[C:23]([O:31][CH3:32])[CH:22]=2)=[O:36])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10]

Participants

4

Reactant 3

HCID 887MethanolHCID 6328Methyl iodideHCID 20034704HCID 20034704, compound

Product 1

HCID 20034702HCID 20034702, compound

Conditions

Temperature
40 °C

Procedure

A solution of 72 g of the compound prepared in (b) above in 96% aqueous methanol was heated to 40° C., after which time 50 ml of iodomethane was added. The reaction mixture was then stirred for 24 hours, while the temperature was maintained at 40° C. The solvent was then evaporated to give an oily residue which was crystallized from a mixture of ethyl acetate and petroleum ether to yield a solid.

Workup

  1. temperaturewas maintained at 40° C
  2. customThe solvent was then evaporated
  3. customto give an oily residue which
  4. customwas crystallized from a mixture of ethyl acetate and petroleum ether
  5. customto yield a solid

Sources & evidence

ORD record
ord-5dd7739490094c098bec4aa6fb9febb5
Source dataset
uspto-grants-1989_07
Patent number
US04845129

Reaction notes

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