3-Benzoylbenzoic acid → 3-Benzylbenzoic acid

HRID 23122노트

반응식

HRID 23122 반응식
[C:1]([C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[C:12]([OH:14])=[O:13])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(OCC)(=O)C.OS(O)(=O)=O.CCCCCC.[Pd]>[CH2:1]([C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[C:12]([OH:14])=[O:13])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

6

반응물 1

HCID 1013863-Benzoylbenzoic acid

생성물 1

HCID 41245533-Benzylbenzoic acid

시약·촉매·용매 4

HCID 23938Palladium촉매HCID 1118Sulfuric Acid용매HCID 8058Hexane용매HCID 8857Ethyl Acetate용매

실험 절차

To a Parr bottle containing 3-benzoylbenzoic acid (0.044 moles) (Aldrich) in 150 mL of ethyl acetate and 4.5 mL of concentrated H2SO4 was added 10 grams of 5% Pd/C. The mixture was hydrogenated on a Parr apparatus under hydrogen (45 psi) overnight. The reaction mixture was then filtered through Hyflo, washing with ethyl acetate. The filterate was dried over Na2SO4, filtered and concentrated to give an oil. The oil was slurried in hexane and the resulting white solid was collected by filtration to afford 3-benzylbenzoic acid, which was used without further purification.

후처리

  1. filtrationThe reaction mixture was then filtered through Hyflo
  2. washwashing with ethyl acetate
  3. dry with materialThe filterate was dried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customto give an oil
  7. filtrationthe resulting white solid was collected by filtration

출처 및 근거

ORD 기록
ord-dd137611086e47af8350281296b6c063
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06849650B2

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