Cyanoacetamide → 4-Cyano-2,3,5,6,7,8-hexahydro-7-methoxy-1-methyl-3-oxoisoquinoline

Participants

Reaction Steps

With 5 ml of ethanol were mixed 1.02 g of 2-acetyl-4methoxycyclohexanone and 0.462 g of cyanoacetamide and, a small quantity of piperidine was added to the mixture followed by heating to reflux for 2 hours. The precipitated crystals were taken out by filtration and recrystallized from methanol to give 0.42 g of 4-cyano-2,3,5,6,7,8-hexahydro-7-methoxy-1-methyl-3-oxoisoquinoline.

Provenance & Evidence