反应详情

40% Boron trifluoride-acetic acid complex, 24 g, was chilled with ice and a mixture of 5.6 g of 4-methylcyclohexanone and acetic anhydride was dropwise added to the complex. After stirring at room temperature for 4 hours, approximately 50 ml of saturated sodium acetate aqueous solution was added to the mixture followed by heating to reflux for 1 hour. After cooling, the reaction mixture was extracted with ether and the extract was washed with a sodium bicarbonate aqueous solution and then water. Thereafter, the system was dried and ether was removed by distillation. The obtained 2-acetyl-4-methylcyclohexanone was used in the whole amount at the following step in a crude state thereof.

1. temperature40% Boron trifluoride-acetic acid complex, 24 g, was chilled with ice
2. additionwas dropwise added to the complex
3. temperatureby heating
4. temperatureto reflux for 1 hour
5. temperatureAfter cooling
6. extractionthe reaction mixture was extracted with ether
7. washthe extract was washed with a sodium bicarbonate aqueous solution
8. customThereafter, the system was dried
9. customether was removed by distillation