HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanoacetamide → 4-Cyano-2,3,5,6,7,8-hexahydro-1-methoxymethyl7-methyl-3-oxoisoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanoacetamide | HCID 7898 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 2-(2-Methoxyacetyl)-4-methylcyclohexan-1-one | HCID 20034908 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-Cyano-2,3,5,6,7,8-hexahydro-1-methoxymethyl7-methyl-3-oxoisoquinoline | HCID 13849812 | — |
Reaction Steps
Crude 2-methoxyacetyl-4-methylcyclohexanone, 3.7 g, 1.68 g of cyanoacetamide and 1 ml of piperidine were mixed with 50 ml of ethanol followed by heating to reflux for 4 hours. The precipitated crystals were taken out by filtration and purified to give 1.5 g of 4-cyano-2,3,5,6,7,8-hexahydro-1-methoxymethyl7-methyl-3-oxoisoquinoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04845228 |
| Source dataset | uspto-grants-1989_07 |
| ORD ID | ord-0a783edd073b4fdea159dddd620c1d6d |
| Source note | uspto-grants-1989_07 |